This is the 9th edition of the PSNC Open Seminars series. On the first day of spring, March 21, 2022 at 2:30 p.m., we cordially invite you to a lecture entitled: “Molecular modelling in the design of drugs acting on the central nervous system”, which will be delivered by Agnieszka A. Kaczor, Prof. UML (Medical University of Lublin). The moderator of the event will be dr Norbert Meyer, Director of Data Processing Technologies Division at PSNC.
The meeting will be organized on the Webex platform on March 21, 2022 at 2:30 p.m.
Prof. Agnieszka A. Kaczor
From 2020, Professor UML of the Department of Synthesis and Chemical Technology of Medicinal Substances with Computer Modelling Lab at Faculty of Pharmacy of the Medical University in Lublin. Author of nearly 150 scientific publications. Agnieszka Kaczor has contributed to the creation of 13 patents.
Since the beginning of her scientific career, associated with the Medical University in Lublin, she completed internships at Pompeu Fabry University in Barcelona, University of Regensburg in Germany and University of Eastern Finland.
Leader of teams studying such issues as new methods of treatment of schizophrenia, Alzheimer’s disease, Parkinson’s disease and depression.
She has been awarded many prizes, including twice the Prize of the Minister of Health for research on new antinociceptive drugs and drugs affecting the central nervous system, the Rector of the Medical University in Lublin award for scientific achievements, the awards of the Polish Chemical Society Member of Polish Societies: Chemical, Biochemical and Medicinal Chemistry.
Main publications:
11. Agnieszka A. Kaczor, Urszula Kijkowska-Murak, Dariusz Matosiuk: Theoretical studies on the structure and symmetry of the transmembrane region of glutamatergic GluR5 receptor, J. Med. Chem. 2008, 51, 3765-3776,
12. Agnieszka A. Kaczor, Urszula Kijkowska-Murak, Christiane Kronbach, Klaus Unverferth, Dariusz Matosiuk: Modelling of glutamate GluR6 receptor and its interactions with novel non-competitive antagonists, J. Chem. Inf. Model., 2009, 49, 1094-1104.
13. Jayendra Z. Patel, Teija Parkkari, Tuomo Laitinen, Agnieszka A. Kaczor, Susanna M. Saario, Juha R. Savinainen, Dina Navia-Paldanius, Maria Teresa Cipriano, Jukka Leppänen, Igor O. Koshevoy, Antti Poso, Christopher J. Fowler, Jarmo T. Laitinen, Tapio Nevalainen: Chiral 1,3,4-oxadiazol-2-ones as highly selective FAAH inhibitors. J. Med. Chem. 2013, 56, 8484-8496.
14. Agnieszka A. Kaczor, Andrea Garcia Silva, Maria Isabel Loza, Peter Kolb, Marian Castro, Antti Poso: Structure-based virtual screening for dopamine D2 receptor antagonists as potential antipsychotics. ChemMedChem 2016, 11, 718-729.
15. Damian Bartuzi, Agnieszka A. Kaczor, Dariusz Matosiuk: Interplay between two allosteric sites and their influence on agonist binding in human μ opioid receptor. J. Chem. Inf. Model. 2016, 56, 563-570.
16. Sari Yrjola, Teija Parkkari, Dina Navia-Paldanius, Tuomo Laitinen, Agnieszka A. Kaczor, Tarja Kokkola, Frank Adusei-Mensah, Juha R. Savinainen, Jarmo T. Laitinen, Antti Poso, Amy Alexander, June Penman, Lisa Stott, Marie Anskat, Andrew J. Irving, Tapio J. Nevalainen: Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists. Eur. J. Med. Chem. 2016, 107, 119-132.
17. Piotr Stepnicki, Magda Kondej, Agnieszka A. Kaczor: Current concepts and treatments of schizophrenia. Molecules 2018, 23, pii: E2087.
18. Magda Kondej, Tomasz M. Wrobel, Andrea G. Silva, Piotr Stepnicki, Oliwia Koszla, Ewa Kedzierska, Agata Bartyzel, Grazyna Biala, Dariusz Matosiuk, Maria I. Loza, Marian Castro, Agnieszka A. Kaczor: Synthesis, pharmacological and structural studies of 5-substituted-3-(1-arylmethyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as multi-target ligands of aminergic GPCRs. Eur. J. Med. Chem. 2019, 80, 673-689.
19. Oliwia Koszla, Przemyslaw Solek, Sylwia Wozniak, Ewa Kedzierska, Tomasz M. Wrobel, Magda Kondej, Aneta Archala, Piotr Stepnicki, Grazyna Biala, Dariusz Matosiuk, Agnieszka A. Kaczor: The antipsychotic D2AAK1 as a memory enhancer for treatment of mental and neurodegenerative diseases. Int. J. Mol. Sci. 2020, 21, 8849.
20. Agnieszka A. Kaczor, Katarzyna M. Targowska-Duda, Piotr Stepnicki, Andrea G. Silva, Oliwia Koszla, Ewa Kedzierska, Angelika Grudzinska, Marta Kruk-Slomka, Grazyna Biala, Marian Castro: N-(3-{4-[3-(trifluoromethyl)phenyl] piperazin-1-yl}propyl)-1H-indazole-3-carboxamide (D2AAK3) as a potential antipsychotic: in vitro, in silico and in vivo evaluation of a multi-target ligand. Neurochem. Int. 2021, 146, 105016.
